DMD # 21154 1 Down - regulation of the carcinogen metabolizing enzyme cytochrome P 450 1 a 1 by vanadium Anwar Anwar - Mohamed and Ayman
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Down-regulation of the carcinogen-metabolizing enzyme cytochrome P450 1a1 by vanadium.
Vanadium (V(5+)), a heavy metal contaminant with important toxicological consequences, has received considerable attention as an anticancer agent, although the mechanisms remain unknown. As a first step to investigate these mechanisms, we examined the effect of V(5+) (as ammonium metavanadate, NH(4)VO(3)) on the expression of the aryl hydrocarbon receptor (AhR)-regulated gene: cytochrome P450 1...
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